Reviewer’s Summary

This work introduces detailed statistical methods using a case study of 12 samples (three arrays at each of four dose levels) and arrays consisting of 16998 genes to make gene expression data available for control and treatment  doses to obtain  isotonic means.  In particular, the connection between Williams' and Marcus' tests and William-type and Marcus-type MCT was addressed to provide clues to a solution to this well known problem, The method was then validated by using FDR and a cited adjusted procedure. Genes found with a larger value of ± are of great interest to genomic scientists for further analysis and investigation

 

 

 

Editorial details below

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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©1996-2009 All Rights Reserved. Online Journal of Bioinformatics.  You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the  before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


Online Journal of Bioinformatics

REFEREE FORM


Please complete and remit to Editorial office, Online Journal of Bioinformatics

Author(s):  Lin D, Shkedy Z, Burzykowski T,  Yekutieli D, De Bondt A, Goehlmann H, Talloen W,  Bijnens L

ID Number: (QWE673/09)
Title: Multiple contrast test for detecting monotonic dose-response relationship and FDR-adjusted confidence intervals for selected parameters in a microarray Setting

 

The Editorial board must ensure that the OJB publishes only papers which are scientifically sound. To achieve this objective, the referees are requested to assist the Editors by making an assessment of a paper submitted for publication by:

(a) Writing a report as described in GENERAL STATEMENTS (Below),
(b} Check the boxes shown below under 1. and  2. ( YES or NO) [N.B.A "NO" assessment must be supported by specific comment in the report.
(c)  Make a recommendation under 3.

The Editor-in-Chief would appreciate hearing from any referee who feels that he/she will be unable to review a manuscript within four weeks.

 

1.      CRITERIA FOR JUDGEMENT (Mark "Yes" or "No").

            General statements

            What is this work about? This work introduces sophisticated statistical methods using a case study of 12 samples to make gene expression data available for control  

             and treatment  doses to obtain  isotonic means.  In particular, the connection between Williams' and Marcus' tests and William-type and Marcus-type MCT was    

            addressed to provide clues to a  solution, The method was then validated by using FDR and a cited adjusted procedure.

              Does it add any value to current knowledge (in this area of bioinformatics)? Yes Genes found with a larger value of ± are of great interest to genomic scientists for further  

                  investigation.

             Is it innovative? Yes (for reasons cited above)

 

Yes/No answers.

 

Is the work scientifically sound? Y

Is the work an original contribution Y
Are the conclusions justified on the evidence presented? Y
Is the work free of major errors in fact, logic or technique? Y
Is the paper clearly and concisely written? Y
Do you consider that the data provided on the care and use of animals (See Instructions to Contributors) is sufficient to establish that the animals used in the experiments were well looked after, that care was taken to avoid distress, and that there was no unethical use of animals? NR


2  PRESENTATION (Mark "Yes" or "No").
 

Does the title clearly indicate the content of the paper?  Y
Does the abstract convey the essence of the article? Y
Are all the tables essential? Y
Are the figures and drawings of good quality? Y
Are the illustrations necessary for an understanding of the text?  Y
Is the labelling adequate? Y


3. RECOMMENDATIONS(Mark one with an X)
 

Not suitable for publication in the OJB
Reassess after major changes
Reassess after suggested changes
Accept for publication with minor changes
Accept for publication without changes X (except that OJB MUST re-FORMAT (not acceptable in current form)


4. REPORT    This is a well written statistical report with high information value. There are no evident mistakes and the paer reads well. This work should be published  without changes

 

©1996-2009 All Rights Reserved. Online Journal of Bioinformatics.  You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the  before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


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